Fig. 1. Putative Raf signalling targets. All functional interactions shown have been described for Raf-1 only, with the exception of MEK phosphorylation which is common to all three Raf proteins. Red arrows with black frames indicate validated substrate phosphorylations, while red arrows indicate suggested substrates. Black arrows are used to describe functional interactions of uncharacterised nature, which may or may not include phosphorylation. See text for details.