Fig. 8. S13A cells abnormally fail to lose polarity and abnormally continue to translocate, albeit at diminished velocity, at the peak and in the back of a simulated temporal wave of cAMP and after the rapid addition of 10^-6 M cAMP. (A,B) Perimeter tracks of representative JH10 and S13A cells, respectively, at the peak and in the back of the second and third waves in a series of four simulated temporal waves generated in the absence of a spatial gradient. (C,D) Perimeter tracks of representative JH10 and S13A cells, respectively, after the rapid addition of 10^-6 M cAMP.