Fig. 1. Hypoxia-induced changes in endothelial cell HS matrix. Changes in the cell-surface-associated GAG content (A), heparan sulfate (B), HS/CS ratio (C) and FGF2-HS binding sites (D) are shown as a ratio between hypoxic and normoxic states for cardiac microvascular endothelial cells (striped bars) and human umbilical vein endothelial cells (gray bars). ^* denotes a significant change in the index under hypoxic versus normoxic conditions (P<0.05). Data are shown as mean±s.d.