Fig. 4. Effects of mAb2 on proteoglycan synthesis and DNA synthesis in chondrocyte cultures, and on DNA synthesis in lymphocyte cultures in the presence or absence of ConA or sConA. (A-C) Poorly differentiated chondrocytes were incubated in the absence or presence of 5 µg ml^–1 ConA or 10 µg ml^–1 sConA with or without mAb2 or control mouse IgG for 24 hours. Alternatively, these cells were exposed to DBcAMP or insulin in the presence or absence of mAb2 at 40 µg ml^–1. (D) Lymphocytes were incubated in the presence or absence of 3 µg ml^–1 ConA with or without mAb2 or control IgG at 40 µg ml^–1 for 72 hours. The values are averages ± s.d. for the four cultures. (A: ConA/sConA versus ConA/sConA + mAb2; *P<0.01; **P<0.005; ***P<0.0001. B: *P<0.01; **P<0.001.)