Fig. 1. Recently identified cargoes for kinesins are built according to a common design plan. With the exception of the transmembrane protein APP, kinesins are linked to cytosolic scaffold proteins that have multiple binding sites for other proteins, including a transmembrane protein that defines the cargo. Kinesin tails and transmembrane receptors are connected to the linkers by modular protein-protein interactions. A large fraction of the linkers discovered thus far are scaffold proteins for signaling pathways.