Fig. 1. F. rubripes scaffolds with two or three keratin genes and the collection of single keratin scaffolds. Scaffolds (Sc), given by number and size, and the areas occupied by the genes are from Table 1. Scaffolds are not drawn to scale. Keratin I and II genes are marked in red and green, respectively. Incomplete genes are marked by an indentation of the colored bars. Notice that four type II genes map next to type I genes, whereas the other two type II genes lie on scaffolds 285 and 3830. Thus, a keratin II gene cluster as in the human genome seems excluded. Also, 13 type I genes occur on seven scaffolds and the other six type I genes lie as single keratin I genes on other scaffolds (Table 1). Although the final view of keratin I gene mapping requires the full F. rubripes genome sequence, current results exclude the pure type I cluster present in the human genome. Other genes present on the scaffolds are given as uncolored boxes. Those with a human counterpart carry the corresponding accession number (Aparicio et al., 2002). These read, from top to bottom: X55733, initiation factor 4B; AB028998, tensin 2; NM_003056, solute carrier family (folate transporter), member 1; AF006085, ARP 2/3 complex subunit 2; M95627, angio-associated migratory cell protein AAMP; AF201422, splicing coactivator subunit SRM300; NM_007153, zinc finger protein 208; AF035262, BAF57; L08176, Epstein-Barr-virus-induced G-protein-coupled receptor; NM_032865, tensin-like protein fragment; AL033533, prostaglandin endoperoxide synthase 2; AB031041, LIM-homodomain protein 6.1a; AAK57478, elongation factor 1A binding protein; AF304450, sarcolemma asociated protein 1; AF298548, caspase recruitment domain protein 7; AAF53869, Drosophila CG13969-PA; 060628, transmembrane 4 superfamily, member 8; J03040, human SPAPC/osteonectin/BM-40; NP_683687, aprataxin, novel nuclear protein; J03537, ribosomal protein S6; L14812, retinoblastoma related protein p107; XP_203519, murine Mycbp-associated protein. Unnamed boxes indicate hypothetical genes.