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Fig. 2. Wnt antagonists and related proteins. (a) sFRP family proteins are related to Frizzled receptors in the CRD (Cysteine-rich domain). NTR, netrin-like domain; CD, cytoplasmic domain. (b) Dickkopf family proteins are related to pancreatic colipase in Cys-2 (Cysteine-rich domain-2). The domain containing 10 conserved cysteine residues in colipase is shown in green. Cys-1, Cysteine-rich domain-1. (c) WIF-1 is related to the receptor tyrosine kinase, RYK in the WIF domain (WD). KD, tyrosine kinase domain. Signal peptides, transmembrane domains and EGF-like repeats are shown as red, blue, and hashed boxes, respectively.