Fig. 1. 3ß1-integrin deficiency does not prevent skin development. 14-day-old WT (A) and 3-integrin-deficient (B) skin grafts developed fully and were covered by dense pelage. H&E-stained sections of WT (C) and 3-integrin-deficient (D) 14-day-old skin grafts. At this stage skin morphology was unaffected by 3-integrin deficiency. Immunofluorescence staining of cryosections using an anti-3-integrin antibody showed that 3-integrin was distributed normally in WT skin grafts (E) and was not detectable in 3-integrin-deficient skin grafts (F). Four skin grafts per genotype and over 160 hair follicles per genotype were analysed. (e) Epidermis; (d) dermis. Bar represents 4 mm in A and B and 100 µm in C-F.