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Fig. 6. Transfected lamin A colocalizes with endogenous lamin B1 at the nuclear rim in MEFs (lmna-/-). Many nuclei in MEFs (lmna-/-) showed `burst ends', or abnormal lamin B1 distribution, at one pole (A). Transfected lamin A colocalized with lamin B1 in these cells (B). Double label with anti-FLAG mAb (red) and rabbit anti-lamin B1 (green). Bars, 10 µm.