Fig. 8. Summary of results of transfection of MEFs with lamin A mutants. The 11-12 exons that encode lamins A and C are shown with amino acid numbers of approximate exon boundaries. The rod region is encoded by exons 1-6 and the common globular tail domain by exons 7-10. Shown below the diagram are mutations that cause EDMD/CMD1A, divided into those that commonly form nuclear foci (`FOCI') and those that rarely form nuclear foci (`RARE FOCI'). Those that form emerin-positive foci are `em+', whereas those that form emerin-negative foci are `em–' (foci were never seen for W520S). Above the diagram is the FPLD mutant, which neither formed foci nor affected emerin interaction. Mutants that retained the ability to recruit emerin to the nuclear rim in MEFs are shown in boldface and underlined.