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Fig. 1. Many PCNA partners share overlapping binding sites. The main regions of the PCNA ring involved in protein-protein interactions are highlighted along with the relevant partners. These are: (1) the interdomain connecting loop (aa L121 to E132; red); (2) the inner side {alpha}-helices at the N-terminus (pink); and (3) the C-terminal tail (blue). For clarity, only one region per each monomer is highlighted. The PCNA structure was generated with the program Swiss-PDBViewer from the PDB file 1AXC, rendered with QuickTime 3D and composed in Adobe PhotoShop.