Fig. 3. An illustration of two functionally important domains on hSpry2 (and other Sprys) and the functions associated with them. The SpryTD (178-282) domain (gold) and the conserved tyrosine phosphorylation sequence (NXYXXXP) (blue). The residues highlighted in red are highly conserved residues that appear to be necessary for the tyrosine phosphorylation-dependent binding of c-Cbl to Spry proteins.