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Fig. 3. Accumulation of DYRK1A in speckle-like compartments is mediated by the histidine domain. Schematically depicted GFP-DYRK1A fusion proteins, containing a region including the NLS2 (378-588), the histidine repeat (590-616) or both (378-616). The amino-acid sequence of the DYRK1A histidine repeat is indicated. Fluorescence images of COS-7 transfected cells are shown.