JCS -- Gidwani et al. 116 (15): 3177 Figure IG7

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Fig. 7. Proposed signaling scheme shows PLD involvement in stimulated PIP₂ production upstream of IP₃-mediated Ca²⁺ release from stores in RBL cells. See text for details. Also indicated are the minimal steps required for Fc ${epsilon}$ RI-mediated exocytosis: PLC ${gamma}$ activation leading to sustained Ca²⁺ mobilization initiated by IP₃-mediated Ca²⁺ release from stores, together with diacylglycerol (DAG)-mediated activation of PKC.