JCS -- Hayakawa et al. 116 (16): 3327 Figure IG7

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Fig. 7. Human HP1 molecular domains. (A) Amino acid sequence of human HP1 subtypes ${alpha}$ , ß, and ${gamma}$ . Asterisks indicate amino acids conserved among the three subtypes and dots indicate amino acids conserved among two of the subtypes. The red-shading is the chromo domain (CD), and the blue shading is the chromo shadow domain (CSD). These domains are connected by the IVR. The domain that mediates centromere localization during metaphase is indicated by a red outline. (B) In interphase, the CD motif (red) is required for localization to centromeric heterochromatin and other heterochromatin, and the CSD motif (blue) is required for localization to PML nuclear bodies. However, during metaphase, centromeric localization of HP1 requires the region containing a portion of the IVR and the CSD motif.