JCS -- Kinoshita et al. 116 (16): 3339 Figure IG3

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Fig. 3. Triple immunostaining of APP, BACE and endosomal (EEA1) (A)/lysosomal (Lamp-1) (B) markers. (A) Co-localization of APP and BACE in endosomes at 15 minutes. At 15 minutes, most signal was found in the endosomes (confirmed by EEA1 staining), showing complete co-localization of APP and BACE. (B) Distinct localization of APP and BACE at 60 minutes. APP signal was found mostly in lysosomes (confirmed by Lamp1), however BACE signal was not. Bar, 20 µm.