Fig. 5. Paraffin sections (5 µm) of wounded epidermis of mouse tail, stained with haematoxylin and eosin. During the first 12 to 24 hours after wounding (A), the incision wound could be recognized as a cut through the epidermis and dermis. On the second day of the healing process (B), the epidermis at the wound edges was thickened and the rounded keratinocytes (see enlargement of boxed area in B) began their migration under the coagulum. Three days after wounding (C), the migrating keratinocytes met under the coagulum, while closing the epidermal wound and beginning with their process of terminal differentiation (see enlargement C). After 4 to 5 days of wound healing (D), the epidermis was again completely stratified (enlargement D). Bars in main images, 250 µm; bars in inserted micrographs, 25 µm. Bs, basal; Co, cornified; Coa, coagulum; E, epidermis; Gr, granulous; Sp, spinous.