Fig. 7. Model explaining the role of 6ß4 integrin in the coordination of migration through EGF. Cells without 6ß4 integrin cannot sustain chemotactic EGFR signals, either from a loss of EGFR/ß4 interactions and/or due to suppression of 3ß1 integrin activity. Upon expression and ligation of 6ß4 integrin, Rac1 activation by EGF is sustained, suppressing 3ß1 integrin and RhoA. 3ß1 integrin is redirected from sites of basal focal contact to sites of cell-cell contact and cells migrate as an integral epithelial sheet.