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Fig. 1. Characterization of transgenic mice. (A) Detection of endogenous and transgenic {alpha}6ß4 by immunofluorescence staining with indicated antibodies; bm, basement membrane; hf, hair follicle. Bar, 50 µm. (B-J) Skin histology of Inv{alpha}6ß4 (E-G), Inv{alpha}6ß4{Delta} (H-G) and wt (B-D) littermate mice 24 hours after a single application of 6 nmol TPA or acetone. Sections in D, G and J were labelled with antibody to BrdU. Bar, 100 µm.