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Fig. 1. Dictyostelium amoebae respond in a unique fashion to four phases of the natural wave of cAMP (16, 17, 26, 31). (A) The spatial, temporal and concentration components of a relayed wave of cAMP in a natural aggregation territory. (B) The protocols for testing the behavior of mutant cells in buffer (i.e., `basic motile behavior') and their responses to the different spatial, temporal and concentration components of a wave.