Fig. 2. A model for nuclear anchorage and migration is shown. The KASH domain (light blue) is targeted to the outer nuclear membrane (ONM) through an interaction with the SUN domain (tan) of UNC-84 (yellow), which may occur through an intermediating protein or complex (gray circle). This predicts that Syne/ANC-1, UNC-84, the nuclear lamina, and other unknown proteins create a bridge across both nuclear membranes. Such a novel mechanism would require that the outer nuclear membrane be independently specified from the endoplasmic reticulum (ER) or nuclear pores (gray). The calponin domains of Syne (red) attach to actin microfilaments (green) to effectively anchor nuclei in the cytoplasm.