Fig. 3. Is there a potential role for Syne/ANC-1 in Muscular Dystrophy? This model points out the similarities between the mechanisms of Syne/ANC-1 and dystrophin. Both of these huge proteins bind to actin through N-terminal calponin domains, and extend spectrin repeats through the cytoplasm. Both then function as part of a bridge across membranes. Mutations in many of these components lead to muscular dystrophy (see text).