Fig. 4. Ionomycin (ION)-induced translocation of cPLA₂ to the nuclear envelope depends on CaM and CaMKII. VSMCs were treated with CaM inhibitor W-7 (10 µM) CaMKII inhibitor KN-93 (10 µM) or their vehicle (VEH). (A) cPLA₂ translocation to the nuclear envelope in cells exposed to 1 µM ION or its vehicle (V) was visualized by confocal microscopy (100x magnification). (B) Density of cPLA₂ fluorescence around the nuclear envelope (n=5). ^*Value significantly different from the corresponding value obtained with V of ION (P<0.05).