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Fig. 1. (A-D) Effect of microinjection of dominant negative mitotic checkpoint proteins on the presence of lagging chromosomes in anaphase in PtK1 cells under different experimental conditions. Arrows point at lagging chromosomes in anaphase. In microinjected cells, the tip of the needle is indicated by an asterisk. Scale bar: 10 µm. A QuickTime movie (Movie 1) of the cell shown in D is available at http://jcs.biologists.org/supplemental/