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Fig. 3. Sources of {alpha}-ketoglutarate in the E2Fa-DPa-overproducing cells. Genes encoding enzymes shown in red and green are up-regulated or down-regulated in the E2Fa-DPa versus wild-type plants, respectively. Products indicated in blue act as precursors for nucleotide biosynthesis. {alpha}-KG, {alpha}-ketoglutarate; GOGAT, glutamate synthase; GS, glutamine synthetase; NIA2, nitrate reductase; NiR, nitrite reductase.