Fig. 10. Model for functional effects of GRIP domain overexpression. (a) Simplified model of vesicular traffic in and out of the TGN in HeLa cells, showing relevant endosomal compartments, the TGN, and the Golgi stack. Early and recycling endosomes are grouped together for simplicity. Cargo following the indicated pathways between organelles are boxed. GRIP proteins or GRIP-interacting molecules are shown to facilitate recycling of proteins from early/recycling endosomes to the TGN. (b) Perturbation of these pathways by overexpression of GRIP domain proteins.