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Fig. 7. Inhibition of contractility using the Rho-kinase inhibitor Y27632, leads to the disappearance of FA and an enrichment of zyxin-free FX. Migrating endothelial cells were treated for 30 minutes with Y27632 or with the serine/threonine kinase inhibitor H-7 (not shown), which block acto-myosin contractility. FA and SF disappear following this treatment, and at the cell periphery, behind an exceptionally broad {alpha}-actinin-rich band, a conspicuous array of FX is apparent. These FX contain paxillin, but not zyxin. Scale bar: 5 µm.