(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 2. Many receptors and second messengers are coupled to the activation of Rap1 guanine nucleotide exchange factors (Rap1GEFs), and an increase in the cellular levels of active, GTP-bound Rap1. Abbreviations used in this figure: ADP, adenosine diphosphate; fMLP, formyl-methionine leucine phenylalanine; LPA, lysophosphatidic acid; DAG, diacyl glycerol; PDGF, platelet-derived growth factor; IFN-{alpha}, alpha-interferon; TCR, T cell receptor; EphK, ephrin kinase; TNF{alpha}, tumor necrosis factor alpha; IL-1, interleukin 1; LPS, lipopolysaccharide; NMDA, N-methyl-D-aspartate; GPCR, G-protein-coupled receptor; RTK, receptor tyrosine kinase (including kinase-associated receptors); DD-R, death-domain-associated receptor. The corresponding bibliographic references are given in the text body.