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Fig. 1. Sequence and structural analysis of MegBP. (A) Amino-acid sequence of a partial MegBP clone isolated from a human brain library by yeast two-hybrid screening. (B) Alignment of the amino-acid sequences of human and murine MegBP assembled from ESTs. The arrow indicates the beginning of the clone identified by the yeast two-hybrid screen. Potential sites for phosphorylation by protein kinase C (*), casein kinase II (•) and tyrosine kinase ({diamondsuit}) are highlighted. (C) Schematic presentation of two tetratrico peptide repeats (TPR-1, amino acids 58-91; and TPR-2, amino acids 313-333) found in MegBP (NCBI database).