JCS -- Ryo et al. 116 (5): 773 Figure IG1

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Fig. 1. A novel post-phosphorylation regulatory mechanism in phosphorylation signaling. Phosphorylation of proteins by proline-directed kinases (e.g. CDKs, MAPKs, GSK-3ß) creates binding sites for the prolyl-isomerase Pin1 (1st step). Subsequent prolyl-isomerization by Pin1 induces conformational changes and thereby regulates the function of target proteins (2nd step).