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Fig. 3. Extension of cellular lifespan of Werner-syndrome fibroblasts following abrogation of p53 function by HPV E6. (A) Growth curve of total cell number versus time for E6-infected AG05229 clone 6. (B) Comparison of growth levels achieved for control (C-1 to C-6) and E6-infected (E6-1 to E6-11) AG05229 clones. E6-p30 is a pooled sample of 30 G418-resistant colonies.