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Fig. 8. Direct signal transmission between mitochondria during apoptosis induced by microscopic photosensitisation. Note the differential behaviour of irradiated and non-irradiated mitochondria, indicative of two phases of signalling between mitochondria. Bcl-2 not only blocks the putative Ca2+-mediated signals between these two populations of mitochondria but also suppresses cyt c release from irradiated mitochondria.