Fig. 8. Model proposing how EAST, as part of an internal nucleoskeleton, could facilitate the congression of chromosomes at prometaphase. Even after nuclear envelope breakdown, chromosomes remain embedded in a nucleoskeleton that constrains their mobility and helps them to remain clustered in the center of the cell. Loss of east might disrupt this structure, causing condensed chromosomes to stray away from the center of the cell or from one another.