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Fig. 2. Regulation of 14-3-3 target binding by protein phosphatases. PP2A directly interacts with BAD, Raf-1 and KSR1, and mediates the dephosphorylation of pS112 on BAD, pS259 on Raf-1 and pS392 on KSR1. PP1 binds Cdc25C and the Ron receptor tyrosine kinase, and dephosphorylates the pS216 site on Cdc25C [exposing a nuclear localization sequence (NLS)] and the pS1394 site on Ron.