JCS -- Bilan et al. 117 (10): 1923 Figure IG2

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Fig. 2. Analysis by iodide efflux assay of CFTR chloride channel activity in the presence of syntaxin 8. (A-C) Iodide effluxes were measured using CHO-CFTR cells ( ${square}$ ) or CFTR and Syn8 transfected CHO-2T cells ( ${blacksquare}$ ). Cells were treated with 2.5 µM forskolin (A), 5 µM forskolin (B) or 250 µM MPB-91 (C) during the interval time indicated by the bar at the top of each panel. (D) Summary of the data collected from 8-16 different experiments using CHO-CFTR cells (empty columns) or CHO-2T cells (filled columns). Data are expressed as a percentage of maximal activity in the presence of the corresponding agent in CHO-CFTR cells. ^***P<0.0001.