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Fig. 3. Metaphase singlets at telomeres do not occur in cancer cell lines. Metaphase cells from two ovarian cancer cell lines, OVCAR-3 (telomerase positive, short telomeres) and SKOV-3 (telomerase positive, long telomeres), were subjected to combined FISH-IF using probes for the telomeric and control regions listed. The mean percentage (±s.d.) of chromosomes displaying a singlet signal in OVCAR-3 and SKOV-3 in comparison to the corresponding percentage in pre-senescent human fibroblast cells is indicated, together with the P value of the binomial distribution probability analysis (*P<0.0001). The number of chromosomes scored for each probe is indicated in the bar.