Fig. 1. Amino acid sequence and scheme of the D. melanogaster lamin B receptor (dLBR) encoded by gene CG17952. (A) Amino acid sequence comparison of the lamin B receptor of human (hLBR), Xenopus laevis (XLBR) and dLBR. The membrane-spanning domains are underlined. The sequence used for the generation of polyclonal antibodies against the Drosophila protein is marked by a dotted line. Amino acids identical in all three species are printed in bold and marked by asterisks. Amino acids that are identical in the two vertebrates are also printed in bold. (B) Schematic drawings of the dLBR, hLBR and XLBR. The positions of individual amino acids are marked by numbers. Boxes depict transmembrane segments (black) and two globular domains (G1, G2; gray) in the N-terminal half of the human and Xenopus LBR; these globular domains are not predicted for the dLBR sequence. The nucleotide sequence of the D. melanogaster gene CG17952 (dLBR) is available under accession number CG17952 of the Berkeley Drosophila Genome Project (BDGP) Database. The corrected sequence of the dLBR shown here is available under accession number AJ606680.