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Fig. 5. (A) Organization of two-pore-domain (2P-domain) K+ channels. P1 and P2 refer to the pore region in the channel monomer. (B) Activation of TREK by membrane stretch is pH dependent and follows a sigmoidal relationship. NPo denotes open probability of N number of TREK channels in the patch. For details see text. (Courtesy of E. Honoré.)