Fig. 10. HET-S(157-289)/GFP aggregates upon transition to the [Het-s] state. Upon transition to the [Het-s] prion state, HET-S(157-289)/GFP forms fibrillar aggregates. Notice that fibrillar aggregates are often not as regular as HET-s(157-289)/GFP aggregates (left). In apical regions (right), donut-shaped circular structures are detected. Scale bar, 2 µm.