Fig. 5. The Raichu-Ras FRET probe. (A) Schematic representation of Raichu-Ras bound to GDP or GTP. (B) EGF activation of Ras. Intensity-modulated display mode (IMD) images of COS-1 cells expressing Raichu-Ras or Raichu-Rap1 and stimulated by EGF. Figure reproduced with permission from the Nature Publishing Group (http://www.nature.com/nature/) (Mochizuki et al., 2001).