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Fig. 5. Integrin {alpha}3ß1-deficient cells fail to polarize and migrate in a persistent and directional fashion. MK+/+ cells, MK–/– cells or MK{alpha}3 cells were plated sparsely onto LN-5 ECM and observed for 2 hours by time-lapse video microscopy. Intervals are indicated in minutes above each column. Arrows mark the position of a short-lived protrusion from an MK–/– cell.