Fig. 1. Schematic representation of hDlg and HTLV-1/HTLV-2 envelope transmembrane proteins. (A) Like other members of the MAGUK subfamily, hDlg is composed of three PDZ domains, one SH3, and one Guanylate kinase-like (GUK) domain. In addition, hDlg possesses a unique proline-rich N-terminal region. The portion of hDlg isolated during the yeast two-hybrid screen is indicated. (B) The transmembrane subunits of HTLV-1 and HTLV-2 envelope glycoproteins are composed of an extracellular domain (EC), a transmembrane domain (TM), and a cytoplasmic domain (CD). The entire primary sequences of the cytoplasmic domains are shown. Conserved consensus motifs involved in the interaction with PDZ domains are shown in grey and underlined.