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Fig. 1. Alfy, a novel human FYVE-domain protein with putative homologues in several species. The presence of known domains in human Alfy and putative Alfy homologues from different species are indicated. Boxes represent conserved regions, whereas dashed lines represent non-conserved regions. The Alfy sequence has been deposited in the EMBL database with accession number AF538685. Putative homologues of Alfy can be found in Drosophila melanogaster (BCHS, AE003611), Caenorhabditis elegans (contig of Z99169+AL032675+Z93390), Dictyostelium discoideum (LvsA, AF088979), Arabidopsis thaliana (AC002330) and Schizosaccharomyces pombe (CAA20312). The mammalian LYST/CHS/Beige protein is also indicated.