Fig. 3. The N-terminal sequence of the KCNQ1 protein. Illustration of the truncation and deletion mutants constructed. An arrow indicates at which residue the sequence starts after the initiation methionine. Broken lines indicate potential sorting signals (LXL and YXX). The highlighted sequence indicates the fragment of 17 residues engrafted into p75NTR (see Fig. 8). The sKvLQT1 sequence is 95 residues shorter than wt-KCNQ1, indicated by 95, and the first 11 amino acids is non-homologous to wt-KCNQ1 (Neyroud et al., 1999).