Fig. 7. Reduced gene dosage of the Drosophila Dock1 homolog, mbc, partially rescues the rough eye phenotype caused by expression of Dab1RFP. (A) The compound eyes of Drosophila with the genotype UAS-RFP/GMR-GAL4 appeared normal as visualized by scanning electron microscopy. (B) Expression of tyrosine-phosphorylated Dab1RFP in Drosophila with the genotype UAS-Dab1RFP/+;GMR-GAL4/+ led to the development of a rough eye morphology characterized by fusions of ommatidia and loss of linearity of the rows of the ommatidial facets (Pramatarova et al., 2003). (C) Heterozygous mutation of mbc partially rescued the developmental phenotype caused by Dab1RFP expression. Drosophila with the genotype UAS-Dab1RFP/+; GMR-GAL4/+; mbc/+ had fewer ommatidial fusions, and the rows of ommatidia are more linear. Magnification: Ai-Ci, 200x (Bar, 100 µm); Aii-Cii, 800x.