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Fig. 4. The PIKE-L/Homer complex couples mGluR to PI 3-kinase and mediates neuronal survival. Through its EVH1 domain, dimerized Homer binds PIKE-L and mGluR1,5 via the `Homer-binding motif'. mGluR1,5 agonists trigger the formation of the PIKE-L/Homer complex and activate PI 3-kinase, enhancing neuronal survival.