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Fig. 1. Altered integrity of actin filaments at specialised microdomains. (A) The microdomain, located at the stress fibre (SF)/focal adhesion (FA) interface features a region where actin filaments fail to become decorated by phalloidin (black bar). Scale bar: 2 µm. (B-D) High molecular mass tropomyosins persist in this gap, demonstrating the continuity of the actin filaments within this microdomain. (E-G) Tropomyosin also concentrates in the `gap' between stress fibre and focal adhesion-targeted {alpha}-actinin. Scale bar in B-G: 5 µm.