Fig. 2. Actin^mut cells are selectively resistant to TNF-induced killing. (A) Wild-type and Actin^mut cells were treated with indicated doses of TNF for 48 hours, H₂O₂ for 9 hours, UV, mytomycin for 96 hours, 5-fluorouracil for 65 hours and vincristine for 96 hours. Cell viability was measured. (B) Wild-type and Actin^mut cells were treated with TNF (100 ng/ml) and/or zVAD (1 µM or 10 µM) in different combinations for 18 hours. Cell viability was measured. Results represent the means±s.e. (n=3).