Fig. 5. The impact of Tiam1 expression on MV3 melanoma proliferation. Equal numbers (5x10⁴) of the indicated cell lines were seeded in culture dishes. Proliferation of control cells (1F6, open triangles; MV3, open circles) and Tiam1-expressing cells (1F6-Tiam1, filled triangles; MV3-Tiam1, filled circles) was monitored over a period of 96 hours, starting one day after seeding. Tiam1 expression remarkably enhanced proliferation of the metastatic cells, whereas proliferation of the non-metastatic cells was slightly reduced.