Fig. 8. Apical-to-basolateral [125I]-RAP ratio over time in megalin (MEGt) and LDL receptor-related protein (LRPt) transfected MDCK cells and control MDCK cells. Basolateral-to-apical efflux of 125I-RAP was significantly lower than the influx and further reduced by stable transfection of LRPt or MEGt.